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脑梗死患者中Hcy、PCT及WBC特点分析及预测价值

论文编号:lw201901251326196143 所属栏目:医学检验论文 发布日期:2019年01月25日 论文作者:论文网
【摘要】目的:研究脑梗死患者中血清同型半胱氨酸(Homocysteine,Hcy)联合血清降钙素原(Procalcitonin,PCT)及白细胞(White Blood Cell,WBC)的特点及预测价值。方法:选取2015年1月-2016年3月医院诊治的脑梗死患者130例,设为观察组,根据出院综合评估分为预后良好组(n=89)和预后不良组(n=41)。选取同期入院健康体检者130例,设为对照组。采用酶法检测Hcy,采用化学发光仪测定PCT,利用XE-5000全自动血液分析仪测定2组WBC水平,分析脑梗死患者中Hcy、PCT及WBC特点及预测价值。结果:观察组Hcy、PCT及WBC水平,显著高于对照组(P<0.05);2组入院第6h、第5天PCT及WBC水平差异无统计学意义(P>0.05);2组治疗后PCT及WBC水平均有所下降,观察组入院第5天PCT及WBC水平,显著低于对照组(P<0.05);脑梗死患者治疗预后与Hcy浓度无相关性(P>0.05);脑梗死患者治疗预后PCT及WBC浓度水平呈正相关性(P<0.05)。结论:脑梗死患者治疗过程中动态检测PCT及WBC水平波动较大,动态监测PCT及WBC水平具有较高的预测价值,值得推广应用,而Hcy浓度则与脑梗死患者治疗预后无相关性。
【关键词】脑梗死;血清同型半胱氨酸;血清降钙素原;白细胞;预测价值
A Study on the Characteristics and Predictive Values of Hcy, PCT and WBC in Patients With Cerebral Infarction
Mao Wan-cheng  Tian Min  Shuai Feng-Fei  Li Li  Zheng Tian-Shun  Zhou Yu-Qin
Sinan County in guizhou province  People Hospitol, 565100;
[Abstract] Objective: To study the characteristics and predictive values of homocysteine (Hcy) combined with procalcitonin (PCT) and white blood cell (WBC) in the patients with cerebral infarction. Methods: Using 130 case of patients from January 2015 to March 2016 with cerebral infarction as the observation group, according to the comprehensive assessment of discharge, it can be divided into good group (n=89) and predicted poor group (n=41). Selecting 130 case of healthy people in the same period as control group. Using enzymatic to examine Hcy, using chemiluminescence to measure PCT, using XE-5000 automated hematology analyzer to measure WBC levels of the two groups, and analyzing the characteristics and predictive value of Hcy, PCT and WBC in patients. Results: The Hcy, PCT and WBC level was higher than control group(P <0.05) significantly; the horizontal of PCT and WBC level for this 2 groups after 6 hours, 5 days was no statistical significance (P>0.05); PCT and WBC levels of 2 groups decreased after treatment, as the observation group,  its PCT and WBC level were lower than the control group (P<0.05) after 5 days significantly; There was no correlation between treating-prognosis patients with cerebral infarction and Hcy concentration (P>0.05); The relation between treating-prognosis patients with cerebral infarction and PCT and WBC levels were positive correlation (P<0.05). Conclusion: In the treatment of patients with cerebral infarction, the dynamic detection of PCT, Hcy and WBC levels fluctuate greatly, and dynamic monitoring of Hcy, PCT and WBC levels have a high predictive value, so it is worth popularizing.
[Key words] cerebral infarction; homocysteine; procalcitonin; white blood cell; predictive value
脑梗死是由于各种因素作用下脑内动脉发生狭窄、闭塞,引起的脑部组织发生急性血液循环障碍的一过性或永久性脑功能损伤,该疾病在老年人群中发生率较高,患者发病后如果得不到及时有效的治疗,将会诱发其他疾病,严重者将威胁患者生命[1]。文献报道显示[2]:动脉粥样硬化是脑梗死的基本病因,动脉粥样硬化斑块形成、发展的过程中炎症反应贯穿其中,直接参与斑块的形成。文献报道显示:血清同型半胱氨酸(Hcy)属于脑梗死患者独立危险因素,Hcy的持续升高能进一步加快斑块的形成,并且血清降钙素原(PCT)、白细胞(WBC)等炎症因子均直接参与其中[3]。为了探讨脑梗死患者中Hcy联合PCT及WBC的特点及预测价值。选取2015年1月-2016年3月医院诊治的脑梗死患者130例,报道如下。
1.资料与方法
1.1临床资料
选取2015年1月-2016年3月医院诊治的脑梗死患者130例,设为观察组,根据出院综合评估分为预后良好组(n=89)和预后不良组(n=41)。其中,男74例,女56例,年龄(46-79)岁,平均(61±2)岁。纳入标准:符合脑梗死临床诊断标准,患者均经过CT或MRI检查得到确诊。选取同期入院健康体检者130例,设为对照组。其中,男67例,女63例,年龄(30-78)岁,平均(60±2)岁。排除标准:①排除不符合临床诊断标准者;②排除合并严重心、肝、肾功能异常者;③排除合并有影响效应指标观测、判断其他生理或病理者。本次临床诊断试验均经患者、家属同意,试验通过医院伦理会批准,患者一般资料差异无统计学意义。
1.2方法
2.结果
2.1 预后良好组和预后不良组入院第6h、第5天PCT及WBC水平比较
2.3 脑梗死与Hcy、PCT及WBC水平相关性比较
3.讨论
【参考文献】
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